SINCE World War II, medical science has progressed to some stage where competitive medications are around for treat precisely the same ailment in several people. It’s not pretty much brands (the industry trade issue) but generic drugs (the industry scientific issue). On this report, we shall consider the various factors that decide the selection of a specific drug.
Safety: The next sub-criteria have to be considered beneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is a particular drug regardless of whether it’s certain side-effects providing the acuteness in the condition is lowered? Example: narcotic pain-killers work well in healing pain but have the possibility side-effect of addiction.
* Long-term safety: medicine may be safe in short-term treatment, so how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and several chemicals reply to make a different chemical, that have an effect which could harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from the other, have certain effects on one or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon because of its metabolism. This causes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually make the same effect on precisely the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both the prescription medication is more intense.
Tolerability: A medicine may be effective and not tolerable by all patients. Example: Allergies to a particular drugs in most people. Short-term and long-term tolerability need to be looked at. Efficacy: A medicine just isn’t equally efficient at all patients. By way of example, some patients with depression or anxiety disorders experience rest from escitalopram, but there are many who don’t, who therefore need to be prescribed some other anti-depressant. The rate of onset of therapeutic action is a vital key to be looked at too.
Cost: Cost doesn’t imply the expense of acquisition of a specific medicine alone. It will also cover the expense of treatment of a complication which could arise from utilizing some other drug. Example: Within a individual that insists on taking alcohol but must be treated for depression is normally administered an SSRI drug as these drugs don’t potentiate the end results of alcohol, whereas another band of anti-depressants (for example tricyclics) can cause a fresh problem in such patients, which will need a different and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram rather than cheaper tricyclic in such patients.
Simplicity of treatment: The easiest mode of administration is preferred. If there is a selection between a shot and oral administration, the latter is preferred if your efficacy of both the modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are key point to make a decision simple treatment.
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