SINCE World War II, medical science has progressed into a stage where competitive medications are around to treat precisely the same ailment in various people. This is not nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall consider the various factors that decide picking a a specific drug.
Safety: These sub-criteria must be considered within the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is really a particular drug even when it’s certain side-effects so long as the acuteness of the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but feature the opportunity side-effect of addiction.
* Long-term safety: drug could possibly be safe in short-term treatment, but how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and several chemicals respond to produce a different chemical, which has an effect which could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of the other person, have certain effects using one or more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by because of its metabolism. This causes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually create the same effect on precisely the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the two medicine is more serious.
Tolerability: A medication could possibly be effective although not tolerable by all patients. Example: Allergies to specific drugs in some people. Short-term and long-term tolerability should be taken into consideration. Efficacy: A medication just isn’t equally efficient at all patients. For example, some patients with depression or anxiety attacks experience rest from escitalopram, but there are numerous that don’t, who therefore should be prescribed an alternative anti-depressant. The speed of start of therapeutic action is a key to be looked at too.
Cost: Cost does not necessarily mean the price tag on acquiring a particular medicine alone. It must also cover the price tag on treatments for a complication which could arise from utilizing an alternative drug. Example: In a individual who insists on taking alcohol and yet must be treated for depression is normally administered an SSRI drug because these drugs don’t potentiate the effects of alcohol, whereas another group of anti-depressants (such as tricyclics) can cause a brand new overuse injury in such patients, which would demand a different and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic in these patients.
Simplicity of treatment: Most effective mode of administration is preferred. If you find an option between a shot and oral administration, the latter is preferred when the efficacy of the two modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are an important factor to make a decision simple treatment.
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