SINCE The second world war, medical science has progressed with a stage where competitive medications are around for treat precisely the same ailment in various people. It’s not just about brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall consider the various factors that decide selecting a particular drug.
Safety: The next sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is really a particular drug even when it’s certain side-effects provided that the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the possibility side-effect of addiction.
* Long-term safety: drug directory may be safe in short-term treatment, but how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and lots of chemicals answer make a different chemical, which has an effect which could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of one another, have certain effects on one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on for its metabolism. This causes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually produce the same influence on precisely the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of the two medicine is more intense.
Tolerability: A drug may be effective but not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability need to be taken into consideration. Efficacy: A drug is just not equally effective in all patients. For instance, some patients with depression or anxiety attacks experience rest from escitalopram, but there are several that do not, who therefore need to be prescribed another anti-depressant. The rate of oncoming of therapeutic action is a the answer to be regarded too.
Cost: Cost doesn’t imply the expense of buying some medicine alone. It should also cover the expense of treatments for a complication which could arise by using another drug. Example: In a one who insists on taking alcohol yet has to be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (for example tricyclics) can cause a new condition in such patients, which may have to have a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram rather than cheaper tricyclic such patients.
Simplicity of treatment: The best mode of administration is preferred. If you find an alternative between a shot and oral administration, the latter is preferred when the efficacy of the two modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to choose simplicity of treatment.
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