SINCE World war 2, medical science has progressed into a stage where competitive medications are around to treat precisely the same ailment in numerous people. It’s not nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). On this report, we shall consider the various factors that decide selecting a specific drug.
Safety: The subsequent sub-criteria should be considered within the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective can be a particular drug even if it has certain side-effects so long as the acuteness with the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but have the possibility side-effect of addiction.
* Long-term safety: medication could possibly be safe in short-term treatment, so how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and lots of chemicals respond to make a different chemical, which has an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of one another, have certain effects on a single or even more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on due to the metabolism. This leads to a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually create the same relation to precisely the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both the medicine is more intense.
Tolerability: A medicine could possibly be effective however, not tolerable by all patients. Example: Allergies to particular drugs in some people. Short-term and long-term tolerability need to be considered. Efficacy: A medicine just isn’t equally great at all patients. As an example, some patients with depression or panic attacks experience rest from escitalopram, but there are lots of that don’t, who therefore need to be prescribed a different anti-depressant. The rate of start of therapeutic action is a vital factor to be looked at too.
Cost: Cost doesn’t imply the price of acquiring some medicine alone. It must also cover the price of treatments for a complication that will arise by using a different drug. Example: Inside a individual that insists on taking alcohol and yet needs to be treated for depression is normally administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another gang of anti-depressants (for example tricyclics) can cause a brand new condition in such patients, which would require a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram rather than cheaper tricyclic in such patients.
Simplicity of treatment: The simplest mode of administration is preferred. If you have a selection between a shot and oral administration, aforementioned is preferred if your efficacy of both the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to choose simple treatment.
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