SINCE World war 2, medical science has progressed to a stage where competitive medications are around for treat precisely the same ailment in different people. This isn’t nearly brands (the trade issue) but generic drugs (the scientific issue). On this report, we shall go through the various factors that decide selecting a particular drug.
Safety: The following sub-criteria should be considered underneath the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is really a particular drug even if it’s got certain side-effects provided that the acuteness of the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the potential side-effect of addiction.
* Long-term safety: medicationdirectory.com might be safe in short-term treatment, but exactly how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and lots of chemicals reply to make a different chemical, which has an effect which could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of each other, have certain effects using one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This makes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually make the same effect on precisely the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both medicines are more intense.
Tolerability: A drug might be effective but not tolerable by all patients. Example: Allergies to a particular drugs in a few people. Short-term and long-term tolerability should be looked at. Efficacy: A drug is not equally good at all patients. For instance, some patients with depression or anxiety attacks experience relief from escitalopram, but there are numerous that don’t, who therefore should be prescribed an alternative anti-depressant. The speed of beginning of therapeutic action is an important key to be looked at too.
Cost: Cost does not necessarily mean the price tag on acquisition of some medicine alone. It must also cover the price tag on treating a complication which could arise from utilizing an alternative drug. Example: Inside a individual that insists on taking alcohol and yet should be treated for depression is usually administered an SSRI drug because they drugs don’t potentiate the end results of alcohol, whereas another group of anti-depressants (like tricyclics) may cause a brand new condition in such patients, which may require a various and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram rather than cheaper tricyclic in these patients.
Simplicity of treatment: The simplest mode of administration is preferred. If you find a selection between a shot and oral administration, the second is preferred in the event the efficacy of both modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key point to determine simple treatment.
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