Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM’s chemical structure. Consequently, SARMs lead to anabolic cellular activity while avoiding many of the negative effects of available given. SARMs happen to be studied inside the treatment of cancer of the breast and cachexia and also have been used as performance-enhancing agents. Here, we evaluate and summarize the actual literature on SARMs.
Aim
To provide the setting, mechanisms, current and potential clinical applications, as well as risks and benefits of SARMs.
Methods
A literature review was performed in MEDLINE while using the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancers, benign prostatic hyperplasia, libido, and muscle tissue. Both preliminary research and scientific studies were included.
Main Outcome Measure
To finish an assessment of peer-reviewed literature.
Results
Although there are currently no U.S. Food and Drug Agency-approved indications for SARMs, investigators are exploring the potential ways to use these compounds. Research has dedicated to the pharmacokinetics and pharmacodynamics of the agents, demonstrating good availability having a paucity of drug interactions. Early clinical studies have demonstrated potential ways to use SARMs within the treating cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancers of the breast, with positive results.
Conclusion
SARMs have some of possible clinical applications, with promise to the safe use in the treating cachexia, BPH, hypogonadism, cancer of the breast, and prostate cancer.
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