Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors based on each SARM’s chemical structure. Consequently, SARMs cause anabolic cellular activity while avoiding most of the negative effects of currently available anabolic steroids. SARMs have already been studied within the treatments for cancers of the breast and cachexia and still have been used as performance-enhancing agents. Here, we evaluate and summarize the actual literature on SARMs.
Aim
Presenting the setting, mechanisms, current and potential clinical applications, in addition to risks and great things about SARMs.
Methods
A literature review was performed in MEDLINE while using terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancers, benign prostatic hyperplasia, libido, and lean muscle mass. Both basic research and clinical studies were included.
Main Outcome Measure
To accomplish an assessment peer-reviewed literature.
Results
However, there are presently no U.S. Drug and food Agency-approved indications for SARMs, investigators are exploring the potential uses of these compounds. Preliminary research has devoted to the pharmacokinetics and pharmacodynamics of these agents, demonstrating good availability having a paucity of drug interactions. Early scientific studies have demonstrated potential ways to use SARMs from the management of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with positive results.
Conclusion
SARMs have numerous possible clinical applications, with promise for the safe used in the management of cachexia, BPH, hypogonadism, cancer of the breast, and cancer of the prostate.
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