SINCE World War II, medical science has progressed to some stage where competitive medications are available to treat the identical ailment in several people. This is simply not just about brands (that is a trade issue) but generic drugs (that is a scientific issue). On this report, we shall consider the various factors that decide picking a a specific drug.
Safety: These sub-criteria have to be considered underneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug regardless of whether it’s certain side-effects providing the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but include the possibility side-effect of addiction.
* Long-term safety: drug directory might be safe in short-term treatment, so how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and a lot of chemicals react to produce a different chemical, which has an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of each other, have certain effects one or even more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on due to the metabolism. This will cause a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually make the same influence on the identical organ, thus helping the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the medicine is more serious.
Tolerability: A drug might be effective and not tolerable by all patients. Example: Allergies to particular drugs in some people. Short-term and long-term tolerability need to be taken into consideration. Efficacy: A drug just isn’t equally efficient at all patients. As an example, some patients with depression or panic attacks experience respite from escitalopram, but there are lots of that don’t, who therefore need to be prescribed some other anti-depressant. The speed of oncoming of therapeutic action is a step to be looked at too.
Cost: Cost does not mean the price tag on acquisition of a particular medicine alone. It ought to also cover the price tag on treatment of a complication that may arise from utilizing some other drug. Example: In the person who insists on taking alcohol and yet needs to be treated for depression is usually administered an SSRI drug since these drugs don’t potentiate the end results of alcohol, whereas another gang of anti-depressants (like tricyclics) might cause a new overuse injury in such patients, which may have to have a different and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than cheaper tricyclic in such patients.
Simplicity of treatment: The easiest mode of administration is preferred. When there is a selection between an injection and oral administration, the latter is preferred if the efficacy of the modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are an important factor to make a decision simple treatment.
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