SINCE World War II, medical science has progressed into a stage where competitive medications are around to treat the identical ailment in various people. This is not nearly brands (the industry trade issue) but generic drugs (the industry scientific issue). With this report, we shall look at the various factors that decide picking a a certain drug.
Safety: These sub-criteria has to be considered under the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is a particular drug even when they have certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the possibility side-effect of addiction.
* Long-term safety: medicine may be safe in short-term treatment, but how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and lots of chemicals answer make a different chemical, which has an effect which could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other person, have certain effects on a single or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon for the metabolism. This will cause a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually generate the same relation to the identical organ, thus helping the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both drugs are more serious.
Tolerability: A medication may be effective but not tolerable by all patients. Example: Allergies to a particular drugs in certain people. Short-term and long-term tolerability have to be looked at. Efficacy: A medication isn’t equally efficient at all patients. By way of example, some patients with depression or anxiety disorders experience reduced escitalopram, but there are several that don’t, who therefore have to be prescribed another anti-depressant. The rate of start of therapeutic action is a crucial step to be regarded too.
Cost: Cost does not necessarily mean the expense of acquisition of a specific medicine alone. It must also cover the expense of treatments for a complication which could arise from utilizing another drug. Example: Within a individual who insists on taking alcohol yet needs to be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (including tricyclics) could cause a fresh problem in such patients, which may demand a various and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than cheaper tricyclic such patients.
Simplicity of treatment: The best mode of administration is preferred. When there is an option between a shot and oral administration, the second is preferred if your efficacy of both modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are a key factor to make a decision simplicity of treatment.
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