SINCE World war 2, medical science has progressed to some stage where competitive medications are for sale to treat precisely the same ailment in various people. This isn’t pretty much brands (that is a trade issue) but generic drugs (that is a scientific issue). With this report, we shall glance at the various factors that decide picking a a particular drug.
Safety: The following sub-criteria must be considered within the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is often a particular drug even if it’s certain side-effects provided that the acuteness with the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the potential side-effect of addiction.
* Long-term safety: medication could be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and several chemicals answer develop a different chemical, that have an effect that will harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from one another, have certain effects one or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This leads to a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually generate the same effect on precisely the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of the two prescription medication is more serious.
Tolerability: A drug could be effective although not tolerable by all patients. Example: Allergies to certain drugs in certain people. Short-term and long-term tolerability need to be looked at. Efficacy: A drug is not equally effective in all patients. For instance, some patients with depression or anxiety disorders experience relief from escitalopram, but there are numerous that do not, who therefore need to be prescribed another anti-depressant. The pace of start of therapeutic action is an important step to be regarded as too.
Cost: Cost doesn’t imply the price tag on purchase of a particular medicine alone. It ought to also cover the price tag on treatment of a complication that will arise while using another drug. Example: Within a one who insists on taking alcohol but has to be treated for depression is normally administered an SSRI drug because they drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (such as tricyclics) could cause a brand new problem in such patients, which would require a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than a cheaper tricyclic in this patients.
Simple treatment: The best mode of administration is preferred. When there is an option between a shot and oral administration, the latter is preferred if your efficacy of the two modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to decide simplicity of treatment.
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